Efficient Maternal to Neonate Transfer of Neutralizing Antibodies after SARS-CoV-2 Vaccination with BNT162b2:A Case-Report and Discussion of the Literature

This case reports on the successful maternal to fetal transfer of neutralizing antibodies after vaccination with BNT162b2 in a pregnant woman at 25 weeks of gestation. The levels of neutralizing antibodies were approximately 5-fold higher in the umbilical cord than in the maternal blood while the level of total antibodies showed only a 2-fold increase. This suggest that the antibodies that crossed the syncytiotrophoblast cell barrier have specific characteristics that correlate to functional neutralizing capacity. Although pregnant and lactating women have been excluded from clinical trials for several reasons including ethical concerns about fetal exposure, accumulating evidence has now revealed that these vaccines are safe and efficient for both the fetus and the woman. Vaccination against COVID-19 in pregnancy is vital to control disease burden and to decrease morbidity in the ante-, peri- and post-natal periods. Inclusion of pregnant women in research programs for the development of SARS-CoV-2 vaccines should be mandatory to provide this population with the equitable benefits of vaccine research

Relativistic Brownian Motion

Stimulated by experimental progress in high energy physics and astrophysics, the unification of relativistic and stochastic concepts has re-attracted considerable interest during the past decade. Focusing on the framework of special relativity, we review, here, recent progress in the phenomenological description of relativistic diffusion processes. After a brief historical overview, we will summarize basic concepts from the Langevin theory of nonrelativistic Brownian motions and discuss relevant aspects of relativistic equilibrium thermostatistics. The introductory parts are followed by a detailed discussion of relativistic Langevin equations in phase space. We address the choice of time parameters, discretization rules, relativistic fluctuation-dissipation theorems, and Lorentz transformations of stochastic differential equations. The general theory is illustrated through analytical and numerical results for the diffusion of free relativistic Brownian particles. Subsequently, we discuss how Langevin-type equations can be obtained as approximations to microscopic models. The final part of the article is dedicated to relativistic diffusion processes in Minkowski spacetime. Due to the finiteness of velocities in relativity, nontrivial relativistic Markov processes in spacetime do not exist; i.e., relativistic generalizations of the nonrelativistic diffusion equation and its Gaussian solutions must necessarily be non-Markovian. We compare different proposals that were made in the literature and discuss their respective benefits and drawbacks. The review concludes with a summary of open questions, which may serve as a starting point for future investigations and extensions of the theory.Comment: review article, 159 pages, references updated, misprints corrected, App. A.4. correcte

Correlations in a non-isothermal plasma

Il est bien connu que dans un plasma à pression suffisamment basse les électrons et les ions peuvent coexister à des températures différentes. Dans ces conditions il devient impossible d’appliquer la distribution canonique pour calculer les corrélations électron-ion ainsi que l’équation d’état. Par contre la méthode développée par l’un de nous (I.P.) et ses collaborateurs permet d’effectuer ce calcul en évaluant les „diagrammes de création” correspondants. Dans cette méthode les corrélations résultent du scattering mutuel des électrons et des ions avec comme condition asymptotique pour t → ∞ la validité des deux distributions de Maxwell.info:eu-repo/semantics/publishe

Equilibrium binary correlations in a classical relativistic homogeneous electron gas

An expression for the binary correlation Fourier transform in a relativistic classical electron gas is derived using the Liouville equation for matter plus field. In many cases, the temperature of matter does not equal that of radiation; it is shown that the two particles correlation depends in a very crucial way on the difference between the particles and field temperatures. The well known cases of the black body and electromagnetic vacuum field distributions are easily recovered. It is shown that due to the absence of the law of action and reaction for electromagnetic forces, no relativistic Boltzmann factor exists in the electromagnetic vacuum case and that the methods of equilibrium statistical mechanics to calculate thermodynamic properties fail. © 1957.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Hydrodynamique statistique des gaz d'électrons relativistes

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

La valeur prédictive de néphro-uropathie des pyélectasies foetales

peer reviewedPyelectasis is a dilatation of the renal pelvis. It must be differentiated from hydronephrosis which is a dilation of the renal pelvis and of the renal calyces. In this retrospective study, we focused on the treatment and follow up of 31 newborns in whom a pyelectasis had been diagnosed in utero. At the end of the study, 20 babies showed no sign of an urologic disorder whereas 11 babies did. Our study suggests that it is crucial to search for an urologic disorder in the neonatal period when a fetal pyelectasis has been diagnosed

Relativistic effects in statistical hydrodynamics

We consider a classical relativistic electron gaz and study the effect of the particles interaction on the macroscopic behaviour of the system. It is shown that due to the non validity of the principle of action and reaction the field surrounding the particles acts as a reservoir of impulsion and energy for the matter; new kinds of motion are permitted due to a source term appearing in the equation of hydrodynamics. © 1957.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Indications for androgen therapy in women

peer reviewedLes taux d’androgènes peuvent être diminués dans de nombreuses situations pathologiques et iatrogènes, mais également physiologiquement chez la femme âgée. La déficience androgénique affecte de nombreux systèmes. La supplémentation androgénique améliorerait les fonctions cognitives, l’humeur, la libido, la qualité osseuse, la force et la fonction musculaire. Toutefois, ce traitement, n’est actuellement pas recommandé en routine par les Guidelines de l’Endocrine Society. Les androgènes peuvent entraîner de l’acné, une augmentation de la pilosité, une raucité de la voix et une clitorimégalie, ces deux derniers effets indésirables étant rares. Ils influencent également le système cardiovasculaire en modifiant le profil lipidique, mais les données restent controversées. La supplémentation par DHEA a été étudiée chez des femmes atteintes d’insuffisance surrénalienne. Il semblerait que 50 mg/j de DHEA soit la dose adéquate pour restaurer des taux d’androgènes physiologiques et améliorer ainsi les symptômes sans observer d’effets secondaires majeurs. Il est toutefois recommandé de poursuivre les recherches parmi les groupes de patientes atteintes de déficience androgénique afin d’en définir précisément le syndrome clinique et d’étudier les effets de l’androgénothérapie